Research into corneal and external eye diseases 

The front of the eye consists of the cornea, the clear outer layer which covers the surface of the eye, and the sclera, the tough ​‘white’ of our eyes.

It’s exposed to the outside world, and so is susceptible to a range of conditions including infections, reactions and dystrophies, all of which can lead to sight loss.

Acanthamoeba keratitis (AK) is an infection of the cornea, caused by a microscopic organism usually found in bodies of water such as rivers, swimming pools or tap water.

It is very rare, extremely painful, and can cause permanent visual impairment or even blindness.

Little is known about this condition and it can be difficult to diagnose because many of the symptoms are similar to other microbial corneal infections.

Some diseases of the front of the eye are relatively mild, but others can lead to significant sight loss.

Treatments for Acanthamoeba keratitis (AK)

There are currently no medicines licensed specifically to treat AK.

It is also particularly difficult to treat because it is resistant to many forms of traditional therapy such as antibiotics.

We’re currently funding a range of research projects looking into corneal and external eye diseases. You can read about some of our most recently funded projects below.