Previously funded projects

Moorfields Eye Charity supports high quality research which has the potential to greatly improve our understanding of vision and eye disease through to the discovery of improved diagnosis, treatments and cures.

Learn more about some work recently funded through our competitive funding calls which are considered three times a year.

Spring 2018 meeting

Lead investigator	Project title	Award total
Prof Rachael Pearson	Development of a visual stimulus-induced flight-based behavioural test for non-invasive assessment of visual function	£100,000
Prof Astrid Limb	Assessment of the neuroprotective ability of Müller glia in an experimental model of high intraocular pressure	£100,000
Prof Karl Matter	Apg-2: At the crossroads of tissue regeneration and degeneration	£100,000
Dr Alice Davidson	Identifying genetic causes, molecular mechanisms and therapeutic strategies for corneal endothelial disease	£112,260
Dr Alice Davidson	Investigating genetic causes and transcriptional dysregulation events associated with posterior polymorphous corneal dystrophy (PPCD)	£100,000

Autumn 2017 meeting

Lead investigator	Project title	Award total
Prof John Greenwood	Bespoke adaptive optics scanning laser ophthalmoscope for evaluation of retinal structure and function in disease	£395,000
Prof Julie Daniels	Ultracentrifugation – A Core Resource for Ophthalmic Eye Research	£66,925
Dr Franziska Bucher	Targeting VEGF-A splice isoforms to modulate corneal innervation and vascularisation	£22,100

Summer 2017 meeting

Lead investigator	Project title	Award total
Prof Rachael Pearson	Determining the role of extracellular vesicles in cytoplasmic material transfer between donor and host photoreceptors after transplantation	£108,698
Prof Michel Michaelides	Deep learning and neural networks for Adaptive Optics image processing in longitudinal studies	£42,539
Prof Alison Hardcastle	Oligonucleotide suppression of mis-splicing of the cone opsin genes as a potential therapeutic for X-linked cone dysfunction	£77,447
Prof Karl Matter	Targeting a new regulatory mechanism to rescue phagocytosis	£40,569

Spring 2017 meeting

Lead investigator	Project title	Award total
Dr Maria Moosajee	Modelling human optic vesicles to dissect the molecular basis of microphthalmia	£100,000
Prof Julie Daniels	GMP validation of RAFT tissue equivalents for clinical trials	£194,244
Dr Patric Turowski	Mitochondrial dynamics in the regulation of pigment epithelium function	£100,000
Mr Ahmad Sajjad	The culture of human corneal endothelial cells for transplantation	£100,000
Prof Alison Hardcastle	Development of iPSC derived corneal cell models of dominant corneal dystrophies	£100,000

Autumn 2016 meeting

Lead investigator	Project title	Award total
Prof Robin Ali	Acquisition of a Bespoke Class II Microbiological Safety Cabinet (MBSC) for the BD Influx Cell Sorter at the Institute of Ophthalmology’s (IoO) FACS Facility	£17,560
Dr Annegret Dahlmann-Noor	Cochrane systematic review of interventions: “Systemic treatment for severe allergic eye disease (atopic and vernal keratoconjunctivitis) in children and young people”	£1,500
Mr Daniel Ezra	An RCT of a patient-initiated botulinum toxin treatment model for blepharospasm and hemifacial spasm compared to standard care	£32,061
Prof Paul Foster	How do mutations in ubiquitous protein, SPATA13, lead to Primary Angle-closure Disease in humans?	£16,750
Dr Anthony Khawaja	Biological pathway discovery for glaucoma through analysis of genetic and real world data	£108,336
Dr Pádraig Mulholland	Quantifying the disease signal to measurement noise ratio with the Moorfields Acuity Chart	£51,932

Summer 2016 meeting

Lead investigator	Project title	Award total
Dr Annegret Dahlmann-Noor	Triple bottom line evaluation of children's eye services at Moorfields Eye Hospital and its satellite sites	£14,500
Mr Gus Gazzard	LiGHT extension: Longitudinal quality of life in a carefully monitored cohort of glaucoma and ocular hypertensive patients	£132,118
Prof Alison Hardcastle and Mr Stephen Tuft	A genome-wide association study of keratoconus	£240,000
Prof Gary Rubin and Dr Pete Jones	To develop interactive 3D visualisations of eye-disease, suitable for mobile phone displays	£14,708

Autumn 2015 meeting

Lead investigator	Project title	Award total
Prof Sir Peng Khaw	Developing a safe and effective drug to block the fibrosis gene pathway in the conjunctive	£82,401
Prof John Marshall	Final laser-dose titration data required to enable reinstatement of clinical trials for the 2RT-mediated laser treatment of dry AMD	£46,530
Prof Paul Foster	Realising the potential of the UK biobank research resource	£44,030
Dr Patrick Yu Wai Man	Investigating disease mechanisms in autosomal dominant optic atrophy with retinal ganglion cells derived from induced pluripotent stem cells	£109,914
Dr Annegret Dahlmann-Noor	Development of objective and self- or proxy-reported outcome measures for clinical trials in childhood blepharokeratoconjunctivitis – an exploratory observational cohort study	£58,007
Prof Maria Balda	GEF-H1 as a drug target for common diseases involving epithelial degeneration	£84,979

Summer 2015 meeting

Lead investigator	Project title	Award total
Prof James Bainbridge	Macular hole imaging by adaptive optics scanning laser ophthalmoscopy	£73,297
Dr Simon Fung	Anterior segment imaging in a paediatric setting	£36,146
Dr Naushin Waseem	Functional characterisation of pigment dispersion syndrome associated mutations in obscurin	£20,000
Mr Ananth Viswanathan	Estimating the incidence of significant visual acuity loss (wipeout) following cataract surgery in patients with glaucoma: a BOSU surveillance study	£13,626
Prof John Greenwood	Investigating the therapeutic potential of targeting LRG1 (leucine-rich alpha-2-glycoprotein-1) in ocular neovascular conditions.	£58,738
Prof Robin Ali	Acquisition of a Vi-Cell XR viability cell analyser for Institute of Ophthalmology’s FACS facility	£42,895
Prof Mike Cheetham	Airy scan super high resolution microscopy	£85,696
Dr Annegret Dahlmann-Noor	The psychological profile of children and young people with medically unexplained visual loss	£26,627
Prof James Bainbridge	Gene therapy vector for children with inherited retinal disease (LCA4)	£300,075
Dr Daniel Gore	A prediction probability model for progression in keratoconus	£5,623

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Previously funded work