Moorfields Eye Charity supports high quality research which has the potential to greatly improve our understanding of vision and eye disease through to the discovery of improved diagnosis, treatments and cures.
Learn more about some work recently funded through our competitive funding calls which are considered three times a year.
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Dr Anthony Robson & Dr Omar Mahroo |
Development and application of artificial intelligence to visual electrophysiology |
£116,358 |
|
Dr Emily Eden |
Membrane contact site expansion as a novel strategy to promote lipid clearance in the retinal pigment epithelium to prevent disease |
£74,841 |
|
Prof Patric Turowski |
Microscope to study the retina and its cellular components in vivo and ex vivo |
£72,497 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Prof Rachael Pearson |
Improving donor-host synaptic connectivity in photoreceptor transplantation: examining the potential role of Wnt signalling |
£69,798 |
|
Dr Omar Mahroo |
Developing a new electrophysiology dark adaptation protocol for the assessment of retinal disease |
£110,000 |
|
Prof Maria Balda |
Small molecule/drug discovery for inhibiion of the GEF-H1/RhoA pathway |
£110,000 |
|
Dr Pearse Keane |
Enabiling the development and application of artificial intelligence in ophthalmology |
£126,873 |
| Dr Tessa Dekker | Neuroscience-based vision tests | £137,013 |
| Dr Nikolas Pontikos | Eye2Gene: assisting diagnosis of inherited retinal diseases with artificial intelligence | £74,577 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Prof Marcus Fruttiger |
Large field image mapping system |
£54,775 |
|
Dr Pearse Keane |
'AI that can build AI' - exploring the feasibility of automated machine learning for medical image classification |
£52,348 |
|
Prof Maria Balda |
GEF-H1 antagonists for the treatment of neovascularization and fibrosis in age-related macular degeneration epithelium |
£117,213 |
|
Dr Thomas Burgoyne |
Docosahexaenoic acid uptake and transport in the retinal pigment epithelium |
£8,991 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Dr Konstantinos Balaskas |
Machine Learning for personalised medicine in neovascular Age-related Macular Degeneration |
£99,506 |
|
Prof Mike Cheetham |
Visual testing for models of blindness |
£54,640 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Prof Rachael Pearson |
Development of a visual stimulus-induced flight-based behavioural test for non-invasive assessment of visual function |
£100,000 |
|
Prof Astrid Limb |
Assessment of the neuroprotective ability of Müller glia in an experimental model of high intraocular pressure |
£100,000 |
|
Prof Karl Matter |
Apg-2: At the crossroads of tissue regeneration and degeneration |
£100,000 |
|
Dr Alice Davidson |
Identifying genetic causes, molecular mechanisms and therapeutic strategies for corneal endothelial disease |
£112,260 |
|
Dr Alice Davidson |
Investigating genetic causes and transcriptional dysregulation events associated with posterior polymorphous corneal dystrophy (PPCD) |
£100,000 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Prof John Greenwood |
Bespoke adaptive optics scanning laser ophthalmoscope for evaluation of retinal structure and function in disease |
£395,000 |
|
Prof Julie Daniels |
Ultracentrifugation – A Core Resource for Ophthalmic Eye Research |
£66,925 |
|
Dr Franziska Bucher |
Targeting VEGF-A splice isoforms to modulate corneal innervation and vascularisation |
£22,100 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Prof Rachael Pearson |
Determining the role of extracellular vesicles in cytoplasmic material transfer between donor and host photoreceptors after transplantation |
£108,698 |
|
Prof Michel Michaelides |
Deep learning and neural networks for Adaptive Optics image processing in longitudinal studies |
£42,539 |
|
Prof Alison Hardcastle |
Oligonucleotide suppression of mis-splicing of the cone opsin genes as a potential therapeutic for X-linked cone dysfunction |
£77,447 |
|
Prof Karl Matter |
Targeting a new regulatory mechanism to rescue phagocytosis |
£40,569 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Dr Maria Moosajee |
Modelling human optic vesicles to dissect the molecular basis of microphthalmia |
£100,000 |
|
Prof Julie Daniels |
GMP validation of RAFT tissue equivalents for clinical trials |
£194,244 |
|
Dr Patric Turowski |
Mitochondrial dynamics in the regulation of pigment epithelium function |
£100,000 |
|
Mr Ahmad Sajjad |
The culture of human corneal endothelial cells for transplantation |
£100,000 |
|
Prof Alison Hardcastle |
Development of iPSC derived corneal cell models of dominant corneal dystrophies |
£100,000 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Prof Robin Ali |
Acquisition of a Bespoke Class II Microbiological Safety Cabinet (MBSC) for the BD Influx Cell Sorter at the Institute of Ophthalmology’s (IoO) FACS Facility |
£17,560 |
|
Dr Annegret Dahlmann-Noor |
Cochrane systematic review of interventions: “Systemic treatment for severe allergic eye disease (atopic and vernal keratoconjunctivitis) in children and young people” |
£1,500 |
|
Mr Daniel Ezra |
An RCT of a patient-initiated botulinum toxin treatment model for blepharospasm and hemifacial spasm compared to standard care |
£32,061 |
|
Prof Paul Foster |
How do mutations in ubiquitous protein, SPATA13, lead to Primary Angle-closure Disease in humans? |
£16,750 |
|
Dr Anthony Khawaja |
Biological pathway discovery for glaucoma through analysis of genetic and real world data |
£108,336 |
|
Dr Pádraig Mulholland |
Quantifying the disease signal to measurement noise ratio with the Moorfields Acuity Chart |
£51,932 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Dr Annegret Dahlmann-Noor |
Triple bottom line evaluation of children's eye services at Moorfields Eye Hospital and its satellite sites |
£14,500 |
|
Mr Gus Gazzard |
LiGHT extension: Longitudinal quality of life in a carefully monitored cohort of glaucoma and ocular hypertensive patients |
£132,118 |
|
Prof Alison Hardcastle and Mr Stephen Tuft |
A genome-wide association study of keratoconus |
£240,000 |
|
Prof Gary Rubin and Dr Pete Jones |
To develop interactive 3D visualisations of eye-disease, suitable for mobile phone displays |
£14,708 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Prof Sir Peng Khaw |
Developing a safe and effective drug to block the fibrosis gene pathway in the conjunctive |
£82,401 |
|
Prof John Marshall |
Final laser-dose titration data required to enable reinstatement of clinical trials for the 2RT-mediated laser treatment of dry AMD |
£46,530 |
|
Prof Paul Foster |
Realising the potential of the UK biobank research resource |
£44,030 |
|
Dr Patrick Yu Wai Man |
Investigating disease mechanisms in autosomal dominant optic atrophy with retinal ganglion cells derived from induced pluripotent stem cells |
£109,914 |
|
Dr Annegret Dahlmann-Noor |
Development of objective and self- or proxy-reported outcome measures for clinical trials in childhood blepharokeratoconjunctivitis – an exploratory observational cohort study |
£58,007 |
|
Prof Maria Balda |
GEF-H1 as a drug target for common diseases involving epithelial degeneration |
£84,979 |
|
Lead investigator |
Project title |
Award total |
|---|---|---|
|
Prof James Bainbridge |
Macular hole imaging by adaptive optics scanning laser ophthalmoscopy |
£73,297 |
|
Dr Simon Fung |
Anterior segment imaging in a paediatric setting |
£36,146 |
|
Dr Naushin Waseem |
Functional characterisation of pigment dispersion syndrome associated mutations in obscurin |
£20,000 |
|
Mr Ananth Viswanathan |
Estimating the incidence of significant visual acuity loss (wipeout) following cataract surgery in patients with glaucoma: a BOSU surveillance study |
£13,626 |
|
Prof John Greenwood |
Investigating the therapeutic potential of targeting LRG1 (leucine-rich alpha-2-glycoprotein-1) in ocular neovascular conditions. |
£58,738 |
|
Prof Robin Ali |
Acquisition of a Vi-Cell XR viability cell analyser for Institute of Ophthalmology’s FACS facility |
£42,895 |
|
Prof Mike Cheetham |
Airy scan super high resolution microscopy |
£85,696 |
|
Dr Annegret Dahlmann-Noor |
The psychological profile of children and young people with medically unexplained visual loss |
£26,627 |
|
Prof James Bainbridge |
Gene therapy vector for children with inherited retinal disease (LCA4) |
£300,075 |
|
Dr Daniel Gore |
A prediction probability model for progression in keratoconus |
£5,623 |