Previously funded work

Moorfields Eye Charity supports high quality research which has the potential to greatly improve our understanding of vision and eye disease through to the discovery of improved diagnosis, treatments and cures. 

Learn more about some work recently funded through our competitive funding calls which are considered three times a year.

 

Spring 2018 meeting

Lead investigator

Project title

Award total

Prof Rachael Pearson

Development of a visual stimulus-induced flight-based behavioural test for non-invasive assessment of visual function

£100,000

Prof Astrid Limb

Assessment of the neuroprotective ability of Müller glia in an experimental model of high intraocular pressure

£100,000

Prof Karl Matter

Apg-2: At the crossroads of tissue regeneration and degeneration

£100,000

Dr Alice Davidson

Identifying genetic causes, molecular mechanisms and therapeutic strategies for corneal endothelial disease

£112,260

Dr Alice Davidson

Investigating genetic causes and transcriptional dysregulation events associated with posterior polymorphous corneal dystrophy (PPCD)

£100,000

 

Autumn 2017 meeting

Lead investigator

Project title

Award total

Prof John Greenwood

Bespoke adaptive optics scanning laser ophthalmoscope for evaluation of retinal structure and function in disease

£395,000

Prof Julie Daniels

Ultracentrifugation – A Core Resource for Ophthalmic Eye Research

£66,925

Dr Franziska Bucher

Targeting VEGF-A splice isoforms to modulate corneal innervation and vascularisation

£22,100

 

Summer 2017 meeting

Lead investigator

Project title

Award total

Prof Rachael Pearson

Determining the role of extracellular vesicles in cytoplasmic material transfer between donor and host photoreceptors after transplantation

£108,698

Prof Michel Michaelides

Deep learning and neural networks for Adaptive Optics image processing in longitudinal studies

£42,539

Prof Alison Hardcastle

Oligonucleotide suppression of mis-splicing of the cone opsin genes as a potential therapeutic for X-linked cone dysfunction

£77,447

Prof Karl Matter

Targeting a new regulatory mechanism to rescue phagocytosis

£40,569

 

Spring 2017 meeting

Lead investigator

Project title

Award total

Dr Maria Moosajee

Modelling human optic vesicles to dissect the molecular basis of microphthalmia

£100,000

Prof Julie Daniels

GMP validation of RAFT tissue equivalents for clinical trials

£194,244

Dr Patric Turowski

Mitochondrial dynamics in the regulation of pigment epithelium function

£100,000

Mr Ahmad Sajjad

The culture of human corneal endothelial cells for transplantation

£100,000

Prof Alison Hardcastle

Development of iPSC derived corneal cell models of dominant corneal dystrophies

£100,000

 

 Autumn 2016 meeting

Lead investigator

Project title

Award total

Prof Robin Ali

Acquisition of a Bespoke Class II Microbiological Safety Cabinet (MBSC) for the BD Influx Cell Sorter at the Institute of Ophthalmology’s (IoO) FACS Facility

£17,560

Dr Annegret Dahlmann-Noor

Cochrane systematic review of interventions: “Systemic treatment for severe allergic eye disease (atopic and vernal keratoconjunctivitis) in children and young people”

£1,500

Mr Daniel Ezra

An RCT of a patient-initiated botulinum toxin treatment model for blepharospasm and hemifacial spasm compared to standard care

£32,061

Prof Paul Foster

How do mutations in ubiquitous protein, SPATA13, lead to Primary Angle-closure Disease in humans?

£16,750

Dr Anthony Khawaja

Biological pathway discovery for glaucoma through analysis of genetic and real world data

£108,336

Dr Pádraig Mulholland

Quantifying the disease signal to measurement noise ratio with the Moorfields Acuity Chart

£51,932

 

 Summer 2016 meeting

Lead investigator

Project title

Award total

Dr Annegret Dahlmann-Noor

Triple bottom line evaluation of children's eye services at Moorfields Eye Hospital and its satellite sites

£14,500

Mr Gus Gazzard

LiGHT extension: Longitudinal quality of life in a carefully monitored cohort of glaucoma and ocular hypertensive patients

£132,118

Prof Alison Hardcastle and Mr Stephen Tuft

A genome-wide association study of keratoconus

£240,000

Prof Gary Rubin and Dr Pete Jones

To develop interactive 3D visualisations of eye-disease, suitable for mobile phone displays

£14,708

 

 

 Autumn 2015 meeting

Lead investigator

Project title

Award total

Prof Sir Peng Khaw

Developing a safe and effective drug to block the fibrosis gene pathway in the conjunctive

£82,401

Prof John Marshall

Final laser-dose titration data required to enable reinstatement of clinical trials for the 2RT-mediated laser treatment of dry AMD

£46,530

Prof Paul Foster

Realising the potential of the UK biobank research resource

£44,030

Dr Patrick Yu Wai Man

Investigating disease mechanisms in autosomal dominant optic atrophy with retinal ganglion cells derived from induced pluripotent stem cells

£109,914

Dr Annegret Dahlmann-Noor

Development of objective and self- or proxy-reported outcome measures for clinical trials in childhood blepharokeratoconjunctivitis – an exploratory observational cohort study

£58,007

Prof Maria Balda

GEF-H1 as a drug target for common diseases involving epithelial degeneration

£84,979

 

Summer 2015 meeting

Lead investigator

Project title

Award total

Prof James Bainbridge

Macular hole imaging by adaptive optics scanning laser ophthalmoscopy

£73,297

Dr Simon Fung

Anterior segment imaging in a paediatric setting

£36,146

Dr Naushin Waseem

Functional characterisation of pigment dispersion syndrome associated mutations in obscurin

£20,000

Mr Ananth Viswanathan

Estimating the incidence of significant visual acuity loss (wipeout) following cataract surgery in patients with glaucoma: a BOSU surveillance study

£13,626

Prof John Greenwood

Investigating the therapeutic potential of targeting LRG1 (leucine-rich alpha-2-glycoprotein-1) in ocular neovascular conditions.

£58,738

Prof Robin Ali

Acquisition of a Vi-Cell XR viability cell analyser for Institute of Ophthalmology’s FACS facility

£42,895

Prof Mike Cheetham

Airy scan super high resolution microscopy

£85,696

Dr Annegret Dahlmann-Noor

The psychological profile of children and young people with medically unexplained visual loss

£26,627

Prof James Bainbridge

Gene therapy vector for children with inherited retinal disease (LCA4)

£300,075

Dr Daniel Gore

A prediction probability model for progression in keratoconus

£5,623