Outbreak of preventable eye infection

Outbreak of preventable eye infection in contact lens wearers

A new outbreak of a rare but preventable eye infection that can cause blindness, has been identified in contact lens wearers in a new study led by UCL and Moorfields Eye Hospital researchers. In the study, supported by funding from Moorfields Eye Charity, research team found a threefold increase in Acanthamoeba keratitis since 2011 in South-East England.

What is Acanthamoeba keratitis?

Acanthamoeba keratitis is an eye disease that causes the front surface of the eye, the cornea, to become painful and inflamed, due to infection by Acanthamoeba, a cyst-forming microorganism.

 

 

According to the findings published today in the British Journal of Ophthalmology, reusable contact lens wearers with the eye infection are more likely to have used an ineffective contact lens solution, have contaminated their lenses with water or reported poor contact lens hygiene.  Lead author, Professor John Dart, UCL Institute of Ophthalmology and Moorfields Eye Hospital NHS Foundation Trust said

“This infection is still quite rare, usually affecting 2.5 in 100,000 contact lens users per year in South East England,* but it’s largely preventable. This increase in cases highlights the need for contact lens users to be aware of the risks,”

The most severely affected patients (a quarter of the total) have less than 25% of vision or become blind following the disease and face prolonged treatment. Overall 25% of people affected require corneal transplants to treat the disease or restore vision.  Anyone can be infected, but contact lens users face the highest risk, due to a combination of increased susceptibility to infection, for reasons not fully established, as a result of contact lens wear and contamination of lens cases.

Irenie Ekkeshis, who is part of Acanthamoeba Keratitis Patient Support Group UK said

This research confirms what those of us affected by Acanthamoeba keratitis have suspected for some time: that incidences of this awful, life-changing infection are on the increase, and there’s more that should be done to prevent people from losing their sight to Acanthamoeba keratitis, “It is absolutely imperative that regulators and those working in the optical sector take the findings seriously, and use the recommendations to take immediate and urgent action on prevention. Contact lenses are medical devices and should be supplied with warnings regarding safe use.

Read more about the study

The researchers collected incidence data from Moorfields Eye Hospital, from 1985 to 2016. They found an increase dating from 2000-2003, when there were eight to 10 cases per year, to between 36-65 annual cases in the past few years. As Moorfields treats more than one in three cases of the disease in the UK, the researchers expect their findings are relevant to the UK more broadly.

Alongside these findings, they conducted a case-control study of people who wear reusable contact lenses on a daily basis (although the disease is also associated with disposable lenses), comparing those who had a diagnosis of Acanthamoeba keratitis to those who had come in to Moorfields A&E for any other reason, from 2011 to 2014.

The case-control study included 63 people with Acanthamoeba keratitis and 213 without. They all completed a questionnaire, from which the researchers found that the risk of developing the disease was more than three times greater amongst people with poor contact lens hygiene, people who did not always wash and dry their hands before handling their lenses, those who used a lens disinfectant product containing Oxipol (now phased out by the manufacturer), and for people who wore their contacts while in swimming pools or hot tubs. Showering and face washing while wearing contact lenses are also likely to be risk factors.

Acanthamoeba is more commonly found in the UK than in other countries, likely due to higher levels found in domestic (as opposed to mains) water supplies, so that water contamination of contact lenses is of particular concern in the UK.

The researchers say the current outbreak is unlikely to be due to any one of the identified risk factors in isolation.

References:

Nicole Carnt, Jeremy J Hoffman, Seema Verma, Scott Hau, Cherry F Radford, Darwin C Minassian, John K G Dart, ‘Acanthamoeba keratitis: confirmation of the UK outbreak and a prospective case control study identifying contributin